The Expression of Secreted Aspartyl Proteinases of Candida Species in Human Whole Saliva

Three distinct secreted aspartyl proteinases in Candida albicans.

The secreted aspartyl proteinases of Candida albicans (products of the SAP genes) are thought to contribute to virulence through their effects on Candida adherence, invasion, and pathogenicity. From a single strain of C. albicans (WO-1) which expresses a phenotypic switching system, three secreted aspartyl proteinases have been identified as determined by molecular weight and N-terminal sequenc...

Proteinases in Virulence and Pathogenesis Secreted Aspartyl Candida albicans

Candida albicans secreted aspartyl proteinases in virulence and pathogenesis.

Candida albicans is the most common fungal pathogen of humans and has developed an extensive repertoire of putative virulence mechanisms that allows successful colonization and infection of the host under suitable predisposing conditions. Extracellular proteolytic activity plays a central role in Candida pathogenicity and is produced by a family of 10 secreted aspartyl proteinases (Sap proteins...

inhibitory effects of carvacrol on the expression of secreted aspartyl proteinases 1-3 in fluconazole-resistant candida albicans isolates

background and objectives: secreted aspartyl proteinase (sap) is one of the main virulence factors in the pathogenesis of candida. this enzyme is encoded by a family of at least ten genes. among these genes, the role of sap1-3 in mucosal infections is evident. this study aimed to investigate the expression of sap1-3 genes of candida albicans isolates after treatmentwith echinophora platyloba ex...

Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells.

The endothelial cell interactions of homozygous null mutants of Candida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicans adherence to endothelial...